Deja Vu I & II for GBC, The Fish Files for GBC, Star Trek the 25th Anniversary for NES, Tombs and Treasure for NES, Shadowgate for NES, Princess Tomato in the Salad Kingdom for NES, King's Quest for SMS, King's Quest V for NES, Phantasy Star Adventure (or Gaiden) for GG (Some similar PS games for Genesis will be added soon).
Also try the
Text Games and some of the Dizzy games.
You can also post a a request in the Game Request thread for Nightshade for NES and Scooby Doo for Genesis and GB. They are point and click games that haven't been added yet.