[Seahawk]

Depends if you mean just the music, or music and sound effects.

For just music, the answer for practical purposes is no. You can try though. On a game, hit Tab to pull up the menu, then hit slider controls. Then you can adjust the volume of each sound channel output from whatever sound chip your game uses. This means you'll have to be familiar with each game and sound chip combination =P. Not recommended.

If you mean all audio from the game, then yes, it's easy. Just hit the tilde (the '~' character, to the left of the '1' key), and bring master volume to 0.